Osteomielitis

Treatment.

Low-differentiated (stem) cells are placed in the special gel that is implanted into the sanified bone defect. These cells produce osteogenic growth factors and but also participate immediately in brain regeneration.

The treatment is conducted in the surgical department.

Infectious safety.

The cells designated for transplantation are prepared under conditions excluding their contamination with pathogenic infectious agents.

Side effects.

Typical surgical complications cannot be entirely excluded.

Clinical effect.

The treatment ameliorates the bone defect.

CELL-BASED TECHNOLOGY FOR CHRONICAL OSTEOMYELITIS

The problem of treating patients with chronical osteomyelitis remains very actual. A cell-based technology of substituting brain defects has been developed in the Center. Fetal-derived or adult bone marrow-derived, low-differentiated (stem) cells are firstly placed in a special gel favorable to cell growth. The cell-containing gel is further implanted within a brain defect. The implanted cells greatly intensify brain reparation. Such treatment is safe and well tolerated. The first results of its applying are very encouraging.

A total of 11 patients aged from 18-to 61 years underwent the cell-based treatment (see table 1).

№ Diagnosis Patient number
1 Chronical hematogenic osteomyelitis of femur 2
2 Chronical posttraumatic osteomyelitis of femur 3
3 Chronical posttraumatic osteomyelitis shank bones 4
4 Chronical posttraumatic osteomyelitis of sternum 1
5 Chronical osteomyelitis sacroiliac articulation (pyogenic sacroileitis) 1

Healing was achieved in 10 patients. A positive effect was noted in the 1 remaining patient with osteomyelitis of sternum, who, however, was unable to complete the treatment because of his arresting. Six patients were followed-up over a long period of time (from 1 to 4 years). None case of disease relapse was noted. Two concrete cases of applying cell-based technology are described below.

Example №1. A 40 year-old female patient underwent osteometalosynthesis by after fracture of the left femur. Posttraumatic osteomyelitis was subsequently developed. For this reason a plate was removed and a framed structure was applied . Later a necrotizing focus (sequestration) of 15 sm long was developed in the shaft of femur (see Figure 1). This focus was resected (see Figure 2) and a brain defect was filled up with a cell implant. Cell transplantation was repeated several times with various time intervals. As a result of such treatment, the secondary clavus was formed (see Figure 3). The patient became able to lean on the left leg and to walk with orthosis.

Figure 1, 2.

Figure 1, 2.

Figure 3.

Figure 3.

Example №2. After sequestrectomy the bone cavity with fistula formed, as can be seen in Figure 4. After several cell implantations the cavity and the fistula were lacking (see Figure 5). The patient could walk sufficiently without any help and had no complains

Figure 4.

Figure 4.

Figure 5.

Figure 5.

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